ASI 染色体比对分析系统
ASI 病理分子影像系统
ASI 频谱影像系统
ASI 染色体核酸探针
LifeCanvas 组织澄清透明化处理系统
UniTMA 组织蜡块制作器
Lumencor 显微镜光源
LCI 显微镜活细胞培养系统
Marzhauser 显微镜用电控载物台
SciMedia 光谱标测系统
.神经膜电位光学标测
.心脏膜电位光学标测
.相关设备及高速相机
显微镜影像系统相关设备
显微注射与其他仪器
Volpi 光源
公司招聘
首頁 > SciMedia 光谱标测系统
心脏膜电位光学标测

SciMedia 具有三款系统供心脏研究, MiCAM ULTIMA & MiCAM02, MiCAM02-CMOS


电压敏感染料的膜电位光学标测技术是细胞分子电生理研究中可以观测微观电兴奋传导唯一对样品可以不接触不穿刺的有效工具。不仅可以多位点同步记录、无损地记录心肌细胞群的膜电位变化,测量细胞与细胞间的电传导,而且可以记录全心脏的电活动,并转化为细胞动作电位以及除极复极等时图、等势图和动作电位时程图等彩色的图像显示。

 

利用此方法, 可以避免外部令人困扰的电磁场干扰,因此已成为研究心脏电除颤等机理较的手段. SciMedia 更开创使用了组同步的高速摄影机, 可以有效应用于多光谱的光学标测, 广泛应用在离子通道, 荧光离子流应用. 此外,在心肌细胞膜电位动态光学成像可以使心脏生理信息检测三维图像可视化。 也可以用于“定量神经电生理学和脑功能成像等领域的研究,为进一步研究人体生理、病理和临床医学诊断, 器官移植, 人造器官, 提供了一种创新方法 .






SciMedia 位居领导地位. 主要原因在于其系统可以实现 :

1.       超高速的高解析, 高灵敏的动态荧光影像

2.       在活体心脏, 可以侦测极低弱的荧光讯号变化.

3.       系统灵活, 软件充分达到研究人员所需.

4.       许多知名的科研文献支持 SciMedia 的傲人成果.

5.       最多人使用, 市占率世界第一.


























2012 part of Reference Papers ( Cardiac Mapping ) ...



Jacob I Laughner, Fu Siong Ng, Matthew S Sulkin, R Martin Arthur and Igor R Efimov  
[Author's HP]

Processing and analysis of cardiac optical mapping data obtained with potentiometric dyes.

Am J Physiol Heart Circ Physiol. 2012 Oct;303(7):H753-65. doi: 10.1152/ajpheart.00404.2012. Epub 2012 Jul 20.
MiCAM ULTIMA Dual Camera System Isolated Heart Voltage Sensitive Dye Calcium Sensitive Dye


Claus Svane Sondergaard, Grant Mathews, Lianguo Wang, Angela Jeffreys, Amrit Sahota, Moira Wood, Crystal M. Ripplinger and Ming-Sing Si

Contractile and electrophysiologic characterization of optimized self-organizing engineered heart tissue.

Ann Thorac Surg. 2012 Oct;94(4):1241-9. doi: 10.1016/j.athoracsur.2012.04.098. Epub 2012 Jul 12.
MiCAM ULTIMA Voltage Sensitive Dye


Ya-Jian Cheng, Di Lang, Shelton D Caruthers, Igor R Efimov, Junjie Chen and Samuel A Wickline  [Author's HP]

Focal but reversible diastolic sheet dysfunction reflects regional calcium mishandling in dystrophic mdx mouse hearts.

Am J Physiol Heart Circ Physiol. 2012 Sep 1;303(5):H559-68. doi: 10.1152/ajpheart.00321.2012. Epub 2012 Jul 9.
MiCAM ULTIMA Isolated Heart Calcium Sensitive Dye


Seth H. Weinberg and Leslie Tung  [Author's HP]

Oscillation in Cycle Length Induces Transient Discordant and Steady-State Concordant Alternans in the Heart.

PLoS One. 2012;7(7):e40477. Epub 2012 Jul 5.
MiCAM ULTIMA Isolated Heart Cultured Cell Voltage Sensitive Dye Calcium Sensitive Dye


Bo Lin, Jong Kim, Yanxin Li, Haiying Pan, Xonia Carvajal-Vergara, Guy Salama, Tao Cheng, Yong Li, Cecilia W. Lo and Lei Yang  

High-purity enrichment of functional cardiovascular cells from human iPS cells.

Cardiovasc Res. 2012 Aug 1;95(3):327-35. Epub 2012 Jun 6.
MiCAM ULTIMA Isolated Heart Voltage Sensitive Dye


Alexandra Traister, Shabana Aafaqi, Stephane Masse, Xiaojing Dai, Mark Li, Aleksander Hinek, Kumaraswamy Nanthakumar, Gregory Hannigan and John G. Coles  

ILK Induces Cardiomyogenesis in the Human Heart.

Med Image Anal. 2012 Feb;16(2):505-23. Epub 2011 Dec 6.
MiCAM ULTIMA Isolated Heart Voltage Sensitive Dye


Mihaela Pop, Maxime Sermesant, Garry Liu, Jatin Relan, Tommaso Mansi, Alan Soong, Jean-Marc Peyrat, Michael V. Truong, Paul Fefer, Elliot R. McVeigh, Herve Delingette, Alexander J. Dick, Nicholas Ayache, Graham A. Wright  

Construction of 3D MR image-based computer models of pathologic hearts, augmented with histology and optical fluorescence imaging to characterize action potential propagation.

Med Image Anal. 2012 Feb;16(2):505-23. Epub 2011 Dec 6.
MiCAM02-HR Isolated Heart Voltage Sensitive Dye


Masaya Watanabe, Hisashi Yokoshiki, Hirofumi Mitsuyama, Kazuya Mizukami, Taisuke Ono, and Hiroyuki Tsutsui  

Conduction and refractory disorders in the diabetic atrium.

Am J Physiol Heart Circ Physiol. 2012 Jul;303(1):H86-95. Epub 2012 May 4.
MiCAM02-HR Isolated Heart Voltage Sensitive Dye


Rachel C. Myles, Lianguo Wang, Chaoyi Kang, Donald M. Bers and Crystal M. Ripplinger  

Local β-Adrenergic Stimulation Overcomes Source-Sink Mismatch to Generate Focal Arrhythmia.

Circ Res. 2012 May 25;110(11):1454-64. Epub 2012 Apr 26.
MiCAM ULTIMA Isolated Heart Voltage Sensitive Dye


Aneesh Bapat, Thao P. Nguyen, Jong-Hwan Lee Ali A. Sovari, Michael C. Fishbein, James N. Weiss and Hrayr S. Karagueuzian  

Enhanced sensitivity of aged fibrotic hearts to angiotensin II- and hypokalemia-induced early afterdepolarization-mediated ventricular arrhythmias.

Am J Physiol Heart Circ Physiol. 2012 Jun 1;302(11):H2331-40. Epub 2012 Mar 30.
MiCAM ULTIMA Isolated Heart Voltage Sensitive Dye


Soban Umar, Jong-Hwan Lee, Enno de Lange, Andrea Iorga, Rod Partow-Navid, Aneesh Bapat, Arnoud van der Laarse, Rajeev Saggar, Rajan Saggar, Dirk L. Ypey, Hrayr S. Karagueuzian and Mansoureh Eghbali  

Spontaneous ventricular fibrillation in right ventricular failure secondary to chronic pulmonary hypertension.

Circ Arrhythm Electrophysiol. 2012 Feb;5(1):181-90. Epub 2011 Dec 22.
MiCAM ULTIMA Isolated Heart Voltage Sensitive Dye


Ohad Ziv, Lorraine Schofield, Emily Lau, Leonard Chaves, Dyviang Patel, Paul Jeng, Xuwen Peng, Bum-Rak Choi and Gideon Koren  

A Novel, Minimally Invasive, Segmental Myocardial Infarction with a Clear Healed Infarct Borderzone in Rabbits.

Am J Physiol Heart Circ Physiol. 2012 Mar 23. [Epub ahead of print]
MiCAM ULTIMA Isolated Heart Voltage Sensitive Dye


Bethany R Desroches, Peng Zhang, Bum-Rak Choi, Michelle E King, Angel E Maldonado, Weiyan Li, Adam Rago, Gong-Xin Liu, Nandan Nath, Kathryn M Hartmann, Bryant Yang, Gideon Koren, Jeffrey R Morgan and Ulrike Mende  

Functional Scaffold-Free 3D Cardiac Microtissues: a Novel Model for the Investigation of Heart Cells.

Am J Physiol Heart Circ Physiol. 2012 Mar 16. [Epub ahead of print]
MiCAM ULTIMA Cultured Cell Voltage Sensitive Dye


Alexey V. Glukhov, Vadim V. Fedorov, Paul W. Kalish, Vinod K. Ravikumar, Qing Lou, Deborah Janks, Richard B. Schuessler, Nader Moazami and Igor R. Efimov  [Author's HP]

Conduction remodeling in human end-stage nonischemic left ventricular cardiomyopathy.

Circulation. 2012 Apr 17;125(15):1835-47. Epub 2012 Mar 12.
MiCAM ULTIMA Isolated Heart Voltage Sensitive Dye


Jacob I. Laughner, Matthew S. Sulkin, Ziqi Wu, Cheri X. Deng and Igor R. Efimov  [Author's HP]

Three Potential Mechanisms for Failure of HIFU Ablation in Cardiac Tissue.

Circ Arrhythm Electrophysiol. 2012 Feb 9. [Epub ahead of print]
MiCAM ULTIMA Isolated Heart Voltage Sensitive Dye



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